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cenobamate will increase the degree or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Intently. Look at a dose reduction of CYP2C19 substrates, as clinically proper, when used concomitantly with cenobamate.diazepam will boost the degree or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4